{"video_id":"O-uwljuMp7w","title":"FIGHT Coronavirus From Home! - Folding@Home","channel":"Techquickie","show":"Techquickie","published_at":"2020-05-05T14:58:16Z","duration_s":326,"segments":[{"start_s":0.08,"end_s":5.359,"text":"when you think of a super computer you probably picture a bunch of server racks","speaker":null,"is_sponsor":0},{"start_s":3.76,"end_s":9.92,"text":"covered in blinking lights and a lab somewhere but did you know that you can","speaker":null,"is_sponsor":0},{"start_s":7.279,"end_s":14.799,"text":"easily make your home pc part of a supercomputer for free and for a good","speaker":null,"is_sponsor":0},{"start_s":12.639,"end_s":19.76,"text":"cause the subject of today's video is a project called folding at home and no","speaker":null,"is_sponsor":0},{"start_s":17.359,"end_s":23.519,"text":"we're not talking about laundry folding at home started at stanford","speaker":null,"is_sponsor":0},{"start_s":21.52,"end_s":28.72,"text":"university but is now run from multiple sites around the world and the goal is","speaker":null,"is_sponsor":0},{"start_s":26.0,"end_s":32.559,"text":"to research protein folding but how does it do this with home computers and what","speaker":null,"is_sponsor":0},{"start_s":30.64,"end_s":36.0,"text":"the heck is protein folding anyway well stay with me here because protein isn't","speaker":null,"is_sponsor":0},{"start_s":34.079,"end_s":40.0,"text":"just the stuff that weight lifters drink by the bucket full your body uses all","speaker":null,"is_sponsor":0},{"start_s":38.48,"end_s":44.079,"text":"sorts of different proteins for everything from building muscle fibers","speaker":null,"is_sponsor":0},{"start_s":41.92,"end_s":48.239,"text":"to inter cellular signaling and the crucial thing to remember about proteins","speaker":null,"is_sponsor":0},{"start_s":45.84,"end_s":52.48,"text":"is that their function depends heavily on their shape which is where the term","speaker":null,"is_sponsor":0},{"start_s":50.879,"end_s":57.28,"text":"folding comes in after a protein is assembled it has to","speaker":null,"is_sponsor":0},{"start_s":54.879,"end_s":60.8,"text":"fold into its proper shape to be useful kind of like how you can't throw a piece","speaker":null,"is_sponsor":0},{"start_s":59.039,"end_s":65.519,"text":"of paper across the room until it's in the correct shape i choose ball but","speaker":null,"is_sponsor":0},{"start_s":63.6,"end_s":69.04,"text":"unlike a paper airplane which you can just follow simple instructions for","speaker":null,"is_sponsor":0},{"start_s":67.439,"end_s":73.04,"text":"protein folding is much more complicated you see proteins","speaker":null,"is_sponsor":0},{"start_s":71.119,"end_s":76.799,"text":"are made up of 20 different kinds of smaller units called amino acids and","speaker":null,"is_sponsor":0},{"start_s":74.96,"end_s":81.759,"text":"while they're structurally similar all 20 of them have different side chains","speaker":null,"is_sponsor":0},{"start_s":79.68,"end_s":86.159,"text":"that as the name implies stick off to the side of the molecule when you","speaker":null,"is_sponsor":0},{"start_s":83.439,"end_s":90.08,"text":"connect a bunch of amino acids together linearly to form a protein these side","speaker":null,"is_sponsor":0},{"start_s":88.4,"end_s":94.0,"text":"chains interact with each other in ways that cause the protein to fold depending","speaker":null,"is_sponsor":0},{"start_s":92.4,"end_s":97.6,"text":"on how they're shaped and their electrical properties as well as you can","speaker":null,"is_sponsor":0},{"start_s":95.92,"end_s":101.92,"text":"imagine the more amino acids the more complicated these interactions become","speaker":null,"is_sponsor":0},{"start_s":99.92,"end_s":106.159,"text":"and a typical protein might be hundreds of amino acid residues long and of","speaker":null,"is_sponsor":0},{"start_s":104.4,"end_s":110.799,"text":"course it's critical for a protein to end up in the correct shape or","speaker":null,"is_sponsor":0},{"start_s":108.24,"end_s":116.159,"text":"conformation because otherwise it couldn't function for example cells have","speaker":null,"is_sponsor":0},{"start_s":113.28,"end_s":119.68,"text":"proteins on their surfaces that serve as signaling receptors and they only","speaker":null,"is_sponsor":0},{"start_s":118.0,"end_s":123.759,"text":"function because they're shaped in a certain way that allows them to bind","speaker":null,"is_sponsor":0},{"start_s":121.759,"end_s":128.64,"text":"with the signaling molecules or other proteins from outside the cell kind of","speaker":null,"is_sponsor":0},{"start_s":126.159,"end_s":132.239,"text":"like two puzzle pieces coming together the tldr is that understanding how","speaker":null,"is_sponsor":0},{"start_s":130.479,"end_s":136.56,"text":"proteins fold has very important implications in medicine for example","speaker":null,"is_sponsor":0},{"start_s":134.879,"end_s":140.959,"text":"understanding how viral proteins interact with cell membranes to invade","speaker":null,"is_sponsor":0},{"start_s":138.64,"end_s":144.879,"text":"cells is critical to finding treatments to some viral diseases so the team","speaker":null,"is_sponsor":0},{"start_s":143.12,"end_s":150.319,"text":"behind the project is currently using folding at home to research the novel","speaker":null,"is_sponsor":0},{"start_s":147.36,"end_s":154.16,"text":"coronavirus that causes covid19 the better we can understand what parts of","speaker":null,"is_sponsor":0},{"start_s":152.0,"end_s":158.4,"text":"the virus especially the ones that bind to human cells could be attacked with","speaker":null,"is_sponsor":0},{"start_s":156.08,"end_s":162.72,"text":"drugs the more likely it is that we can develop medicines that can treat or cure","speaker":null,"is_sponsor":0},{"start_s":160.56,"end_s":166.879,"text":"the disease but anyways this is Techquickie not biology quickies so let's","speaker":null,"is_sponsor":0},{"start_s":164.959,"end_s":171.599,"text":"tie this all back to the folding at home project it turns out that simulating","speaker":null,"is_sponsor":0},{"start_s":169.12,"end_s":176.0,"text":"protein folding patterns is very difficult computationally in nature","speaker":null,"is_sponsor":0},{"start_s":174.0,"end_s":181.2,"text":"proteins fold in a tiny fraction of a second but it can take years of computer","speaker":null,"is_sponsor":0},{"start_s":178.8,"end_s":186.319,"text":"time to sort out exactly how a protein will fold given a certain amino acid","speaker":null,"is_sponsor":0},{"start_s":183.68,"end_s":190.72,"text":"sequence and a big part of the problem is that we don't yet fully understand","speaker":null,"is_sponsor":0},{"start_s":188.239,"end_s":194.879,"text":"the mechanisms behind protein folding so the idea behind folding at home is to","speaker":null,"is_sponsor":0},{"start_s":192.56,"end_s":199.12,"text":"leverage spare home computing power in order to solve these difficult problems","speaker":null,"is_sponsor":0},{"start_s":197.28,"end_s":203.36,"text":"all you need to do to participate like i am is install a client onto your home pc","speaker":null,"is_sponsor":0},{"start_s":201.519,"end_s":207.36,"text":"from the folding at home website the program will then give your system part","speaker":null,"is_sponsor":0},{"start_s":205.28,"end_s":212.08,"text":"of a folding simulation to run and then send back to the program servers you can","speaker":null,"is_sponsor":0},{"start_s":209.68,"end_s":216.239,"text":"specify how much of your pc spare computing muscle to use depending on how","speaker":null,"is_sponsor":0},{"start_s":214.239,"end_s":219.84,"text":"much you want to affect your power bill and you can also choose whether to run","speaker":null,"is_sponsor":0},{"start_s":217.92,"end_s":223.36,"text":"the simulations only when the system is idle or also when you're actively using","speaker":null,"is_sponsor":0},{"start_s":221.84,"end_s":226.4,"text":"them or maybe you choose depending on how hot","speaker":null,"is_sponsor":0},{"start_s":224.879,"end_s":229.519,"text":"your house is already if you have a high-end graphics card","speaker":null,"is_sponsor":0},{"start_s":228.08,"end_s":232.799,"text":"you're going to help even more the highly parallel nature of GPU","speaker":null,"is_sponsor":0},{"start_s":231.28,"end_s":237.2,"text":"architectures which you can learn more about up here can really speed up","speaker":null,"is_sponsor":0},{"start_s":234.879,"end_s":240.72,"text":"simulations but you also don't need super fancy hardware the current version","speaker":null,"is_sponsor":0},{"start_s":239.12,"end_s":245.36,"text":"of the client supports cpus all the way back to pentium 4. now it might seem","speaker":null,"is_sponsor":0},{"start_s":243.28,"end_s":249.04,"text":"like the impact one system makes on the project is","speaker":null,"is_sponsor":0},{"start_s":246.56,"end_s":253.2,"text":"minuscule but all that spare computing power really adds up and taken","speaker":null,"is_sponsor":0},{"start_s":250.959,"end_s":257.04,"text":"collectively the folding at home network is up there with the world's top super","speaker":null,"is_sponsor":0},{"start_s":254.959,"end_s":260.079,"text":"computers this has enabled real scientific breakthroughs that would have","speaker":null,"is_sponsor":0},{"start_s":258.639,"end_s":263.28,"text":"been much harder to reach otherwise hundreds of scientific papers have been","speaker":null,"is_sponsor":0},{"start_s":261.759,"end_s":266.96,"text":"published from the project's findings and they've also been useful for those","speaker":null,"is_sponsor":0},{"start_s":264.8,"end_s":271.6,"text":"involved in drug discovery so if you can spare a bit of power download the","speaker":null,"is_sponsor":0},{"start_s":269.199,"end_s":275.919,"text":"folding at home app today join the LTT folding team and make a difference your","speaker":null,"is_sponsor":0},{"start_s":273.6,"end_s":280.08,"text":"pc might even wind up finding a cure for the coronavirus which could not only","speaker":null,"is_sponsor":0},{"start_s":277.68,"end_s":283.52,"text":"save lives but also finally put an end to all these people hoarding toilet","speaker":null,"is_sponsor":0},{"start_s":281.68,"end_s":286.479,"text":"paper what's up with that anyway geez it doesn't make you poo more you poo the","speaker":null,"is_sponsor":0},{"start_s":284.96,"end_s":289.6,"text":"same amount anyway this video is brought to you by","speaker":null,"is_sponsor":0},{"start_s":288.0,"end_s":293.52,"text":"freshbooks freshbooks allows you to easily manage your backend processes so","speaker":null,"is_sponsor":1},{"start_s":291.759,"end_s":297.68,"text":"that you can spend more time focusing on your main business automatic late","speaker":null,"is_sponsor":1},{"start_s":295.759,"end_s":301.36,"text":"payment reminders let you avoid awkward conversations with clients about overdue","speaker":null,"is_sponsor":1},{"start_s":299.52,"end_s":305.52,"text":"payments and award-winning customer service allows you to handle situations","speaker":null,"is_sponsor":1},{"start_s":303.28,"end_s":308.479,"text":"without having to wait just take photos of your receipts to automatically log","speaker":null,"is_sponsor":1},{"start_s":306.88,"end_s":311.759,"text":"them onto your account and select to apply them to invoices you can get 50","speaker":null,"is_sponsor":1},{"start_s":310.56,"end_s":316.72,"text":"off your first three months of fresh books when you sign up for a paid plan","speaker":null,"is_sponsor":1},{"start_s":313.84,"end_s":319.52,"text":"at freshbooks.com forward slash tech wiki so thanks for watching guys if you","speaker":null,"is_sponsor":1},{"start_s":318.24,"end_s":324.72,"text":"liked this video give it a thumbs up get subscribed and hit us up in the comments section with your suggestions","speaker":null,"is_sponsor":0},{"start_s":323.199,"end_s":327.36,"text":"for topics that we should cover in the future","speaker":null,"is_sponsor":0}],"full_text":"when you think of a super computer you probably picture a bunch of server racks covered in blinking lights and a lab somewhere but did you know that you can easily make your home pc part of a supercomputer for free and for a good cause the subject of today's video is a project called folding at home and no we're not talking about laundry folding at home started at stanford university but is now run from multiple sites around the world and the goal is to research protein folding but how does it do this with home computers and what the heck is protein folding anyway well stay with me here because protein isn't just the stuff that weight lifters drink by the bucket full your body uses all sorts of different proteins for everything from building muscle fibers to inter cellular signaling and the crucial thing to remember about proteins is that their function depends heavily on their shape which is where the term folding comes in after a protein is assembled it has to fold into its proper shape to be useful kind of like how you can't throw a piece of paper across the room until it's in the correct shape i choose ball but unlike a paper airplane which you can just follow simple instructions for protein folding is much more complicated you see proteins are made up of 20 different kinds of smaller units called amino acids and while they're structurally similar all 20 of them have different side chains that as the name implies stick off to the side of the molecule when you connect a bunch of amino acids together linearly to form a protein these side chains interact with each other in ways that cause the protein to fold depending on how they're shaped and their electrical properties as well as you can imagine the more amino acids the more complicated these interactions become and a typical protein might be hundreds of amino acid residues long and of course it's critical for a protein to end up in the correct shape or conformation because otherwise it couldn't function for example cells have proteins on their surfaces that serve as signaling receptors and they only function because they're shaped in a certain way that allows them to bind with the signaling molecules or other proteins from outside the cell kind of like two puzzle pieces coming together the tldr is that understanding how proteins fold has very important implications in medicine for example understanding how viral proteins interact with cell membranes to invade cells is critical to finding treatments to some viral diseases so the team behind the project is currently using folding at home to research the novel coronavirus that causes covid19 the better we can understand what parts of the virus especially the ones that bind to human cells could be attacked with drugs the more likely it is that we can develop medicines that can treat or cure the disease but anyways this is Techquickie not biology quickies so let's tie this all back to the folding at home project it turns out that simulating protein folding patterns is very difficult computationally in nature proteins fold in a tiny fraction of a second but it can take years of computer time to sort out exactly how a protein will fold given a certain amino acid sequence and a big part of the problem is that we don't yet fully understand the mechanisms behind protein folding so the idea behind folding at home is to leverage spare home computing power in order to solve these difficult problems all you need to do to participate like i am is install a client onto your home pc from the folding at home website the program will then give your system part of a folding simulation to run and then send back to the program servers you can specify how much of your pc spare computing muscle to use depending on how much you want to affect your power bill and you can also choose whether to run the simulations only when the system is idle or also when you're actively using them or maybe you choose depending on how hot your house is already if you have a high-end graphics card you're going to help even more the highly parallel nature of GPU architectures which you can learn more about up here can really speed up simulations but you also don't need super fancy hardware the current version of the client supports cpus all the way back to pentium 4. now it might seem like the impact one system makes on the project is minuscule but all that spare computing power really adds up and taken collectively the folding at home network is up there with the world's top super computers this has enabled real scientific breakthroughs that would have been much harder to reach otherwise hundreds of scientific papers have been published from the project's findings and they've also been useful for those involved in drug discovery so if you can spare a bit of power download the folding at home app today join the LTT folding team and make a difference your pc might even wind up finding a cure for the coronavirus which could not only save lives but also finally put an end to all these people hoarding toilet paper what's up with that anyway geez it doesn't make you poo more you poo the same amount anyway this video is brought to you by freshbooks freshbooks allows you to easily manage your backend processes so that you can spend more time focusing on your main business automatic late payment reminders let you avoid awkward conversations with clients about overdue payments and award-winning customer service allows you to handle situations without having to wait just take photos of your receipts to automatically log them onto your account and select to apply them to invoices you can get 50 off your first three months of fresh books when you sign up for a paid plan at freshbooks.com forward slash tech wiki so thanks for watching guys if you liked this video give it a thumbs up get subscribed and hit us up in the comments section with your suggestions for topics that we should cover in the future"}